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Treatments / Microneedling & Mesotherapy / Microneedling Skin Renewal with Polynucleotides (PN)

Microneedling Skin Renewal with Polynucleotides (PN)

Microneedling with polynucleotides (PN) to support deep hydration, elasticity, and collagen stimulation for resilient, healthier-looking skin.

Price

Starting from $285 USD

Exclusive Pricing

A targeted renewal protocol that pairs a high performance facial with regenerative Microneedling to brighten, smooth texture, and support firmer, healthier looking skin.

Promo package

Valid until 2026-12-31

Available on Tuesday

Skin Renewal Package

Price includes one HydraFacial and one Microneedling or Mesotherapy session.
Offer available for purchase on Tuesdays only.

Skin Renewal Package - PN: $340 USD

Promo package

Valid until 2026-12-31

Available on Tuesday

3 Session Collagen Boost

Per-session rate applies when all three sessions are purchased together.
Sessions may be redeemed at different times.
Offer available for purchase on Tuesdays only.
May be shared with friends or family.

3 Session Collagen Boost - PN (per session): $250 USD

Promo package

Valid until 2026-03-14

Casmara Infinity AntiAging Facial + PN

Includes one Casmara Infinity AntiAging facial (face only).
Includes an exclusively priced polynucleotide Microneedling or mesotherapy treatment.
Treatment zones can be Face, Face + Neck, or Face + Neck + Decollete.

Casmara Infinity AntiAging Facial + PN - Face: $345 USD

Casmara Infinity AntiAging Facial + PN - Face + Neck: $495 USD

Casmara Infinity AntiAging Facial + PN - Face + Neck + Decollete: $600 USD

Promo package

Valid until 2026-03-14

Casmara Purifying Algae Facial + PN

Includes one Casmara Purifying Algae facial (face only).
Includes an exclusively priced PN Microneedling or mesotherapy treatment.
Treatment zones can be Face, Face + Neck, or Face + Neck + Decollete.

Casmara Purifying Algae Facial + PN - Face: $335 USD

Casmara Purifying Algae Facial + PN - Face + Neck: $485 USD

Casmara Purifying Algae Facial + PN - Face + Neck + Decollete: $590 USD

Promo package

Valid until 2026-03-14

Casmara Retinol ProAge Facial + PN

Includes one Casmara Retinol ProAge facial (face only).
Includes an exclusively priced PN Microneedling or mesotherapy treatment.
Treatment zones can be Face, Face + Neck, or Face + Neck + Decollete.

Casmara Retinol ProAge Facial + PN - Face: $340 USD

Casmara Retinol ProAge Facial + PN - Face + Neck: $490 USD

Casmara Retinol ProAge Facial + PN - Face + Neck + Decollete: $595 USD

Polynucleotides are delivered through precision microchannels to support cellular renewal, barrier quality, and firmness over a treatment series. A strong option for dull, fragile, or aging skin profiles.

3-6 sessions recommended for optimal results
Safe for most skin types
Downtime: 1-3 days of redness possible

Pricing Options and Add Ons

Face

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.

Price:$300 USD

Exclusive pricing:$245 USD

Face + Neck

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.

Price:$450 USD

Exclusive pricing:$395 USD

Face + Neck + Decollete

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.

Price:$565 USD

Exclusive pricing:$500 USD

Small Zone

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.
Total area [103 cm - 413 cm ]. Approximately one to two palms similar to a credit card up to half a sheet of paper.

Price:$285 USD

Exclusive pricing:$225 USD

Medium Zone

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.
Total area [523 cm - 1080.3 cm ]. Four to six palms roughly the size of a full sheet of paper.

Price:$465 USD

Exclusive pricing:$425 USD

Large Zone

PN (Polynucleotide)
Stimulates collagen and cellular renewal support to improve elasticity, texture, and skin resilience for a healthier-looking feel.
Total area [1264 cm - 2090 cm ]. Eight to twelve palms about the size of a square pillow or large square.

Price:$575 USD

Exclusive pricing:$520 USD

All prices are listed in either USD or MXN as indicated. If payment is made in a different currency than the one listed, for example paying in pesos for a USD listed price or vice versa, the final price will be calculated using Mave Medical Spa’s current internal exchange rate at the time of payment.

Available Protocol Packages

Promo package

Valid until 2026-12-31

Skin Renewal Package

PN: $340 USD

Promo package

Valid until 2026-12-31

3 Session Collagen Boost

PN (per session): $250 USD

Promo package

Valid until 2026-03-14

Casmara Infinity AntiAging Facial + PN

Casmara Infinity AntiAging Facial + PN - Face: $345 USD

Casmara Infinity AntiAging Facial + PN - Face + Neck: $495 USD

Casmara Infinity AntiAging Facial + PN - Face + Neck + Decollete: $600 USD

Promo package

Valid until 2026-03-14

Casmara Purifying Algae Facial + PN

Casmara Purifying Algae Facial + PN - Face: $335 USD

Casmara Purifying Algae Facial + PN - Face + Neck: $485 USD

Casmara Purifying Algae Facial + PN - Face + Neck + Decollete: $590 USD

Promo package

Valid until 2026-03-14

Casmara Retinol ProAge Facial + PN

Casmara Retinol ProAge Facial + PN - Face: $340 USD

Casmara Retinol ProAge Facial + PN - Face + Neck: $490 USD

Casmara Retinol ProAge Facial + PN - Face + Neck + Decollete: $595 USD

Add On Options

Allergan Aesthetics Neuromodulator - Any Zone

EXCLUSIVE PROMO AVAILABLE

Neuromodulators at Mave Medical Spa utilize Botulinum Toxin Type A to temporarily relax muscles responsible for dynamic expression lines. We work with premium international laboratories and high-purity counterparts to ensure consistent, natural-looking results. This medical treatment effectively softens forehead lines, crow’s feet, and frown lines, with results typically lasting 3 to 4 months.

Price: From $5.50 USD

Learn More About Allergan Aesthetics Neuromodulator - Any Zone

Hydrafacial MD - Face

EXCLUSIVE PROMO AVAILABLE

Experience a medical-grade HydraFacial in Tijuana featuring patented Vortex-Fusión technology for deep pore cleansing, comfortable extractions, and intense skin hydration. Perfect for acne-prone, dry, or congested skin.

Price: From $95 USD

Learn More About Hydrafacial MD - Face

Casmara - Retinol ProAge Facial

EXCLUSIVE PROMO AVAILABLE

Professional-strength retinol treatment designed to promote cellular renewal, improve texture, and reduce fine lines.

Price: From $5 USD

Learn More About Casmara - Retinol ProAge Facial

Janssen - Ultra Renewal Facial - Face

A gentle yet effective AHA and peptide-based peel that stimulates skin renewal and refines texture.

Price: From $5 USD

Learn More About Janssen - Ultra Renewal Facial - Face

PDO Thread Lift - Signature Lower Face Lift

EXCLUSIVE PROMO AVAILABLE

PDO biostimulating threads are designed to improve skin quality from within by activating the bodys natural collagen production. This treatment focuses on firmness, texture, and long-term skin health rather than lifting or repositioning tissue.

Price: From $75 USD

Learn More About PDO Thread Lift - Signature Lower Face Lift

Sylfirm X - RF Microneedling - Face

Dual-wave Radiofrequency (RF) Microneedling is a high-performance technology used to lift, tighten, and resurface skin tissue. By delivering controlled thermal energy into the dermis, it triggers a healing response that treats skin laxity, scarring, and redness. This treatment is safe for all skin types and requires minimal downtime for significant rejuvenation.

Price: From $400 USD

Learn More About Sylfirm X - RF Microneedling - Face

What to Expect

Avoid retinoids, AHAs/BHAs, exfoliation, and waxing for 3-5 days prior; no recent sunburn or tanning.
Arrive with clean skin (no makeup); reschedule if you have active infection, open wounds, or flare of cold sores without prophylaxis.
Limit alcohol, NSAIDs, and blood-thinning supplements 24-48 hours before if medically permitted.

Frequently Asked Questions

Expert Aesthetic Care — Just Minutes from the Border

Our Tijuana med spa serves clients from San Diego, LA, Tijuana and beyond!

Offering advanced treatments in rejuvenation from Collagen Biostimulators, Sylfirm X RF microneedling, PDO threads, and facial balancing.

Schedule your consultation and get a personalized plan tailored to your goals.

Flexible Packages with Exclusive Savings

Get long-lasting aesthetic results without paying full price upfront. Our multi-session packages are perfect for U.S. patients crossing from San Diego and Tijuana locals alike.

Your Plan Includes:

Special pricing on bundled services which include Collagen Biostimulators (with PLLA, CAHA + Hyaluronic Acid), RF Microneedling (Sylfirm X), and more.
Only 20% deposit required per session so you can skip the financial pressure of full prepayment. Your deposit is fully credited toward your next visit.
Personalized plans combining advanced technologies and proven aesthetic techniques for natural-looking, long-term skin rejuvenation.
Doctor-led care at every stage to ensure safe, effective results from Tijuana’s trusted medical spa professionals.